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CBD for the endocannabinoid system


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The relationship between the endocannabinoid system (ECS) and the metabolic health benefits of exercise


Estimated reading time: 11 minutes

Table of Contents
Endocannabinoid system
The Runners High and CBD
CBD, sports, physiology and bioenergetics
Our appetite and CBD
Cannabidiol for the gut microbiome
Our health and the microbiome
CBD for digestive health
CBD research
What is the epithelial barrier?
Findings from the study
Endocannabinoid system

Scientists discovered in the early 2000s that circulating levels of endocannabinoids in the human body increased during exercise. The term “running record” took on a new meaning. According to a 2004 article in Runner’s World, experts were already questioning the old endorphin model. Turning to cannabinoids, specifically, anandamide binds to the CB1 receptor and produces both pain-killing and euphoric effects.

But the situation was far from resolved. Research into the exact origin and role of the endocannabinoid system (ECS) continued in the 2010s. The basic effects of endocannabinoid production during exercise are now accepted. Deeper aspects of this relationship are still being explored. including the legality of using cannabis for athletic performance; The relationships between THC consumption and physical activity, and other aspects of ECS function. After all, exercise affects systems throughout the body, including heart rate and breathing, metabolism and mental health.

Let’s look at how CBD for the endocannabinoid system can be affected by exercise.

The Runners High ו-CBD

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Just a few months ago, The Neuroscientist, a journal aimed at doctors and nurses, published a review with a striking title. “Do endocannabinoids cause a runner’s high?” – Evidence and unanswered questions. Exercise increases endocannabinoids in the body. These appear to be associated with runner’s highs, meaning lower levels of anxiety and feeling high. Also proves less pain following physical activity.

The article ends with a recipe for stimulating the release of endocannabinoids in the laboratory. According to the study, running is the best way to increase endocannabinoid levels in the blood. Then cycling, and the duration should be at least 20 minutes. The authors also note that 30 to 35 minutes of exercise produces the greatest positive mood effects.

What more..

In addition to showing these broad trends, the analysis revealed several inconsistencies. There were significant differences in effect size between studies. It is related to the training intensity, physical fitness, measurement timing and/or fasting state. The effects of chronic or long-term exercise on circulating endocannabinoids were also inconsistent. shows that temporarily high levels during exercise are associated with a transient “runner’s high”.

CBD, sports, physiology and bioenergetics


CBD may not have a direct effect on the runner’s high, but its potential to enhance exercise should not be overlooked. With its indirect interactions with both CB1 and CB2 receptors, as well as activity at a variety of other receptors, CBD is known to provide a variety of physiological benefits, including pain and inflammation relief, and stress reduction.

In fact, a recent study published in the International Journal of Molecular Sciences highlights the link between the endocannabinoid system (ECS) and the metabolic health benefits of exercise. The researchers note that ECS dysregulation can lead to insulin resistance, type 2 diabetes and other metabolic imbalances, all of which can be corrected through regular exercise.

While much of this research is still in its early stages, the potential of tailored exercise regimens to treat and prevent these dangerous conditions is a promising area for further investigation. So while CBD won’t directly affect a runner’s high, it certainly has a role in improving overall physical health and well-being.

Our appetite and CBD

The endocannabinoid system (ECS) regulates our appetite, satiety and weight when it is working properly. CB1 cannabinoid receptors in our brain are responsible for signaling that it is time to eat when we are hungry. Stimulate our appetite and sharpen our sense of smell so that the food tastes even better. Activation of the CB2 cannabinoid receptor, on the other hand, works to reduce food consumption and prevent fat accumulation in the body.

When only fresh meat, fruits and vegetables were available to eat, it was easier to naturally balance our ECS. However, our modern diets are so messed up that our CB1 receptors are stuck in overdrive. Strengthening the feed-reward-overfeeding loop from all the sweet and high-fat foods we consume.

When mice were fed a high-fat, high-sugar diet for 60 days, their CB1 receptors became overactive. Preventing the secretion of amino acids that should reduce appetite when the system is working properly. Our CB2 receptors, on the other hand, are activated by plant foods such as leaves and bitters, olive oil and various spices. They are actually malnourished on a typical Western diet high in carbohydrates and processed food.

Your gut has its own “brain”, which communicates with the brain between your ears.

A lack of omega-3 fatty acids also changes how our cannabinoid receptors work. These beneficial fatty acids keep our ECS functioning smoothly. However, if you are deficient in omega-3 fatty acids (as many Americans are), your ECS function suffers.

Cannabidiol for the gut microbiome

Your gut microbiome does more than just aid in digestion. It is linked to your overall well-being, including your moods and emotions, through the gut-brain axis. This is a critical relationship that medical scientists are paying more and more attention to because it affects inflammation, digestion, and even your mental health. The endocannabinoid system (ECS) plays a key role in regulating the gut-brain axis, enabling communication between the brain and the microbiome. This means that if your diet negatively affects your microbiome, it can also affect your ECS and brain function.

Regular exercise is essential for maintaining a healthy ECS. Exercise releases natural endocannabinoids that help regulate stress levels and maintain a healthy weight. Unfortunately, many of us spend most of our time sitting, whether at a desk, in the car or on the couch, leading to a sedentary lifestyle that can have a negative impact on our health.

The microbiome is a vast community of microorganisms that live both in and on our bodies. It is estimated to contain the same number of cells as the human body and encodes 100 times more genetic material than the human genome. The gut alone contains up to 1,000 different species of bacteria. With this understanding, it is clear that the health of our microbiome is essential to our overall health and well-being.

Our health and the microbiome

As research into the human microbiome continues to advance, it has become increasingly clear that it plays a vital role in overall health and well-being. This complex ecosystem of microorganisms, which resides in the gut, has been linked to a variety of health problems including obesity, cancer and neurological diseases such as Parkinson’s and Alzheimer’s. Although much is still unknown about the workings of the microbiome, one crucial factor that has been overlooked is the role of the endocannabinoid system (ECS).

Despite the extensive attention given to the microbiome in the popular media, the relationship between the ECS and the microbiome has received little coverage outside of scientific circles. The ECS is a complex system of receptors and signaling molecules that helps regulate a variety of physiological processes, including appetite, mood, and inflammation. Studies have shown that the ECS also plays a role in regulating the activity of the microbiome, which in turn has implications for overall health and well-being.

As we continue to unravel the complex interplay between the microbiome and the ECS, it is becoming increasingly clear that this relationship has important implications for human health. By better understanding the role of the ECS in shaping the microbiome, we may be able to develop new treatments and interventions for a variety of health problems, from obesity to neurological diseases.

The role of the endocannabinoid system

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The ECS, according to current thinking, acts as a kind of bridge between bacteria and the body. Here we can include the brain, sending signals back and forth in a symbiotic, mutually beneficial relationship. At least, that’s how it should be. But a chronic imbalance or damage to the gut microbiome can be harmful to both physical and mental health.

Humans and other animals affect the “bugs” in their intestines mainly through diet. including consumption of so-called probiotic foods that promote a healthy microbiome. These insects, in turn, help break down food and make nutrients available to the body. We give them food and a comfortable place to live. They then help us extract as much nutrition as possible from the food in the digestive system.

That’s amazing in itself. However, it turns out that this is not enough. Groundbreaking research has revealed that we can influence our gut microbiome with more than just exercise and certain medications.


CBD for digestive health

The interactions of gut microbiota and the endocannabinoid system were first studied in 2010. A Belgian research team discovered a change in the gut microbiome of obese mice with prebiotics. Including foods that encourage the growth of beneficial bacteria. This altered ECS expression in adipose tissue, which may affect lipid metabolism and fat cell formation.

The ECS acts as a link between bacteria and the human body. including the brain, transmitting signals in a symbiotic, mutually beneficial relationship.

CBD research

The bacteria in our intestines have a vital role besides breaking down food. They also play a crucial role in regulating the epithelial barrier, which is a protective layer lining the digestive tract.

The composition of our microbiome is determined by a variety of factors, not just our diet, and these microorganisms help maintain the integrity of the intestinal barrier. But how exactly do they achieve this important role?

Endocannabinoid system for pets

מערכת ECS באינפוגרפיקה של כלבים

The endocannabinoid system (ECS) is a very interesting part of the complex body of our companion pets. This system, found in all mammals, is very important for maintaining balance and strengthening general health. Let’s go on an adventure to understand how the endocannabinoid system works in pets. Gaining a better understanding of its inner workings.

The endocannabinoid system consists of three main parts: enzymes, endocannabinoids and receptors. These parts work together to make the body’s biological responses sound like a symphony. The receptors are called cannabinoid receptors type 1 (CB1) and type 2 (CB2). They are found in many different organs and tissues. The way our pets function is intricately woven into their bodies.

Endocannabinoids, produced by the body naturally, act as signals in this system. They attach to the cannabis receptors like puzzle pieces that fit together well. With this complicated dance, a flood of information is sent out. They stimulate a number of physical processes that help maintain the body’s balance and make it function properly.

Read more about CBD for pets here

What is the epithelial barrier?

According to Keith Sharkey, a professor and researcher at the University of Calgary who has studied the gut for decades. He recently showed that the microbiome, the ECS, and the epithelial barrier play a huge role in maintaining overall health and warding off disease. He was also senior author of the aforementioned 2015 study in which mice were given THC.

The epithelial barrier is critical for homeostasis, or normal body functions. The body manages the control of this delicate lining very carefully. As mammals, we have developed a complex control system that prevents or repairs damage quickly. In order to prevent further aging of our body. This system is helped by the bacteria in our intestines. And the ECS seems to be a critical control element.

Findings from the study

Everything points in the same direction. If the ECS interacts with both the gut barrier and the microbiome, both are critical to human health. We also know that we can influence the ECS through diet, exercise and cannabis products. There may be other ways to target the microbiome through the ECS to achieve specific health outcomes.

Groundbreaking research has shown that we can influence our gut microbiome. Not only through diet, exercise and certain medications, but also through the consumption of CBD, all through the ECS.

Is it possible for the gut microbiome to change these cannabinoids, making them more or less active?